Response to rapamycin analogs in PTEN-mutated lung cancer – Video abstract [ID 161738]

18 May 2018 04:20 0
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Video abstract of Case report paper “Response to rapamycin analogs but not PD-1 inhibitors in PTEN-mutated metastatic non-small-cell lung cancer with high tumor mutational burden” published in the open access journal Lung Cancer: Targets and Therapy by Parikh et al.

In non-small-cell lung cancer (NSCLC) refractory to standard therapy and which lacks well-known oncogenic drivers, genomic profiling can still identify genomic alterations that may suggest potential sensitivity to targeted therapy. PTEN mutation in NSCLC may be sensitizing to analogs of rapamycin such as everolimus or temsirolimus, but more investigation is needed. We report the case of a patient with metastatic NSCLC harboring a PTEN mutation as well as high tumor mutational burden and PD-L1 positivity with a durable response to temsirolimus, but refractory to a checkpoint inhibitor. Even in the event of failure of treatment with checkpoint inhibitors in the background of a case with a higher tumor mutational burden and PD-L1 positivity, targeting specific genomic alterations may still result in patient benefit.

Read the case report here: https://www.dovepress.com/response-to-rapamycin-analogs-but-not-pd-1-inhibitors-in-pten-mutated--peer-reviewed-article-LCTT

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