Huntington disease is caused by a mutation in the HTT gene. Understanding how the mutation causes neurodegeneration might help researchers develop treatments that protect brain function. This animation describes the genetic defect that underlies Huntington disease. Created by the editors at Nature Reviews Disease Primers.
Learn more about Huntington disease with the Primer http://dx.doi.org/10.1038/nrdp.2015.5 and PrimeView http://go.nature.com/hPMENh