F- GLUTATHIONE©, NOW WITH MULTIPLE SYSTEM ATROPHY (MSA) HAS SHOWED A DEFINITE SOLUTION

22 Nov 2011 00:56 0
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MULTIPLE SYSTEM ATROPHY (MSA) is a DEGENERATIVE NEUROLOGICAL DISORDER. MSA is associated with the degeneration of nerve cells in SPECIFIC AREAS OF THE BRAIN. This cell degeneration causes problems with movement, balance and other autonomic functions of the body such as bladder control or blood pressure regulation.

The cause of MSA is unknown and no specific risk factors have been identified.[2] Around 55% of cases occur in men, with typical age of ONSET IN THE LATE 50S TO EARLY 60S.[3]

MSA is characterized by a combination of the following, which can be present in any combination:

• AUTONOMIC DYSFUNCTION

• PARKINSONISM (muscle rigidity +/ tremor and slow movement)

• ATAXIA (Poor coordination / unsteady walking)

When AUTONOMIC FAILURE PREDOMINATES, the term SHY-DRAGER SYNDROME is sometimes used, although this term is no longer current, given the terminology changes which are explained below.[7] This syndrome was named after Dr Milton Shy and Dr Glenn Drager, who identified it in 1960, but the American Autonomic Society and the American Academy of Neurology redefined it as multiple system atrophy with autonomic phenomena in 1996

A variant with combined features of MSA and Lewy body dementia may also exist.[11]

INITIAL PRESENTATION

The most common first sign of MSA is the appearance of an "akinetic-rigid syndrome" (i.e. SLOWNESS OF INITIATION OF MOVEMENT RESEMBLING PARKINSON'S DISEASE) found in 62% at first presentation.

Other common signs at onset include problems with balance (cerebellar ataxia) found in 22% at first presentation, followed by GENITO-URINARY PROBLEMS (9%).

For men, the first sign can be erectile dysfunction (inability to achieve or sustain an erection).

Both men and women often experience problems with their bladders including urgency, frequency, incomplete bladder emptying or an inability to pass urine (retention). About 1 in 5 MSA patients will suffer a fall in their first year of disease.

These common first signs are the same as those of subacute combined degeneration of the spinal cord, which is caused by vitamin B12 deficiency: Patients present with weakness of legs, arms, trunk, tingling and numbness that progressively worsens. Vision changes and change of mental state may also be present.

Bilateral spastic paresis may develop and pressure, vibration and touch sense are diminished. A positive Babinski sign may be seen.

Prolonged deficiency of vitamin B12 leads to irreversible nervous system damage Vitamin B12 should be tested directly; it cannot be ruled out by a complete blood count. In the age of folic acid fortification, patients will not have macrocytic anemia.

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