Somatic copy number gains of SNCA in Parkinson’s disease and multiple system atrophy brains

10 Jul 2018 04:59 0
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The alpha-synuclein protein is important in the pathogenesis of synucleinopathies, but mutations in the SNCA gene are very rarely found. Mokretar et al. demonstrate somatic copy number gains of SNCA in a small proportion of substantia nigra dopaminergic neurons, commoner in Parkinson’s disease, and possibly multiple system atrophy, than controls.

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