Mastizaade is about Lily Lele and Laila Lele (both played by Sunny Leone), twin sisters who organise a treatment center for sex addicts. Sunny Kele (Tusshar Kapoor) and Aditya Chothia (Vir Das) are two spoilt brats who are sex-addict, meet the twin sisters and fall in love with each. Deshdrohi and Deshpremi (both played by Shaad Randhawa) are two look-alikes, Deshpremi is physically disabled and Deshdrohi is an womanizer. Lily and Deshpremi are about to get married. The story revolves around the various twists and funny chaos in their lives.